APOE modulates ferroptosis to drive macrophage polarization toward the M2 type and enhance PTC migration and invasion
Background: Previous studies have found that Apolipoprotein E (APOE) plays a crucial role in invasion and migration of papillary thyroid carcinoma (PTC) cells and enhance M2 macrophage polarization.Ferroptosis has been implicated in development of various tumors and their treatment resistance, and studies have shown that APOE is involved in ferropt